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(R)-GSK-F1

R Isomer of GSK-F1

(R)-GSK-F1 is the R-isomer of GSK-F1, a selective inhibitor of phosphatidylinositol 4-kinase alpha (PI4KA). It exhibits potent inhibitory activity with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9, and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG, and PI3KD, respectively. This compound is primarily utilized in research related to hepatitis C virus (HCV) infection, making it a valuable tool for studying PI4K signaling pathways and their implications in viral pathogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1384097-28-2
Applications	R Isomer of GSK-F1
Formula	C₂₇H₁₈F₅N₅O₄S
Molecular Weight	603.52
SMILES	O=C1C2=C(N=C(N1C3=C(C(F)(F)F)C=CC=C3)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.