Fig. 1 · Structure
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(R)-I-BET762 carboxylic acid
R-enantiomer of I-BET762 carboxylic acid
(R)-I-BET762 carboxylic acid is the R-enantiomer of the I-BET762 carboxylic acid compound. This molecule acts as a ligand for conjugation reactions in proteolysis-targeting chimeras (PROTACs) aimed at bromodomain and extra-terminal (BET) proteins. It exhibits significant inhibitory activity against BRD4, with a pIC50 value of 5.1, making it a valuable tool for studies investigating BET-related pathways in cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1786401-70-4 |
| Applications | R-enantiomer of I-BET762 carboxylic acid |
| Formula | C20H17ClN4O3 |
| Molecular Weight | 396.83 |
| Synonyms | (R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2 |
| SMILES | CC1=NN=C2[C@@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.