Fig. 1 · Structure
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(R)-Lanicemine
iGluR Antagonist
(R)-Lanicemine is an antagonist of ionotropic glutamate receptors (iGluRs), specifically acting as a low-trapping NMDA channel blocker. It exhibits activity with a Ki value ranging from 0.56 to 2.1 μM for the NMDA receptor, and IC50s of 4-7 μM in CHO cells and 6.4 μM in Xenopus oocyte cells. This compound is primarily utilized in research related to depression and neuropharmacology, highlighting its potential for therapeutic applications in mood disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 190581-71-6 |
| Applications | iGluR Antagonist |
| Formula | C13H14N2 |
| Molecular Weight | 198.26 |
| Synonyms | (R)-AZD6765 |
| SMILES | N[C@@H](C1=CC=CC=C1)CC2=CC=CC=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.