Fig. 1 · Structure
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(R)-M8891
M8891 Isomer
(R)-M8891 is a less active isomer of M8891, targeting Methionine Aminopeptidase-2 (MetAP-2) as a reversible inhibitor. This compound demonstrates brain penetration and has been characterized for its oral bioavailability. It is utilized in research applications involving protein synthesis regulation and potential therapeutic interventions in diseases influenced by MetAP-2 activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2575547-29-2 |
| Applications | M8891 Isomer |
| Formula | C20H17F2N3O3 |
| Molecular Weight | 385.36 |
| SMILES | O=C([C@@]1(O)C(N(C2=CC3=C(NC=C3)C=C2)CC1)=O)NCC4=CC(F)=CC(F)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.