Fig. 1 · Structure
Documents & Downloads
(R)-MDL-101146
HNE Inhibitor
(R)-MDL-101146 is a competitive and reversible inhibitor targeting human neutrophil elastase (HNE), with a Ki value of 25 nM. This compound demonstrates significant inhibition of HNE-induced hemorrhage in preclinical models, highlighting its potential in respiratory and inflammatory diseases. Research applications include emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome, and glomerulonephritis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 163660-53-5 |
| Applications | HNE Inhibitor |
| Formula | C29H37F5N4O6 |
| Molecular Weight | 632.62 |
| SMILES | CC(C)[C@@H](C(N1[C@H](C(N[C@H](C(C)C)C(C(C(F)(F)F)(F)F)=O)=O)CCC1)=O)NC(C2=CC=C(C(N3CCOCC3)=O)C=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.