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(R)-MK-8353

R-enantiomer of MK-8353

(R)-MK-8353 is a selective and orally bioavailable inhibitor of ERK1 and ERK2, demonstrating IC50 values of 23.0 nM and 8.8 nM, respectively. This R-enantiomer of MK-8353 is valuable for research into MAPK signaling pathways, particularly in the context of cancer and other diseases associated with abnormal ERK activity. Its potency makes it a useful tool for elucidating the role of ERK in cellular processes and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2748457-30-7
Applications	R-enantiomer of MK-8353
Formula	C₃₇H₄₁N₉O₃S
Molecular Weight	691.84
Synonyms	(R)-SCH900353
SMILES	O=C([C@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.