Fig. 1 · Structure
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(R)-Nepicastat hydrochloride
DBH Inhibitor
(R)-Nepicastat hydrochloride is a selective and potent inhibitor of dopamine-beta-hydroxylase (DBH). It demonstrates concentration-dependent inhibition of DBH activity in both bovine (IC50 = 8.5 nM) and human (IC50 = 9 nM) sources. This compound is capable of crossing the blood-brain barrier, making it suitable for research applications related to neurological disorders and the modulation of catecholamine levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 195881-94-8 |
| Applications | DBH Inhibitor |
| Formula | C14H16ClF2N3S |
| Molecular Weight | 331.81 |
| Synonyms | (R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride |
| SMILES | S=C1NC=C(CN)N1[C@H]2CC3=C(C(F)=CC(F)=C3)CC2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.