Fig. 1 · Structure
Documents & Downloads
(R)-Odafosfamide
DNA-alkylating Agent
(R)-Odafosfamide is a prodrug that targets DNA through its selective conversion by aldo-keto reductase 1C3 (AKR1C3) into a potent DNA-alkylating agent. It demonstrates significant anticancer activity and is relevant for research on hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL). This compound serves as a valuable tool for investigating mechanisms of DNA damage and therapeutic resistance in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2097713-68-1 |
| Applications | DNA-alkylating Agent |
| Formula | C21H25N4O6P |
| Molecular Weight | 460.42 |
| Synonyms | OBI-3424; TH-3424; (R)-AST-3424 |
| SMILES | O=P(N1CC1)(N2CC2)O[C@@H](C3=CC=C([N+]([O-])=O)C(OC4=CC=CC(C(N(C)C)=O)=C4)=C3)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.