Fig. 1 · Structure
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(R,R)-BMS-986397
CK1α Degrader
(R,R)-BMS-986397 is a potent CK1α degrader, exhibiting a degradation concentration (DC50) range of 0.1-0.5 pM. This compound is instrumental in studying the role of CK1α in cellular processes and has applications in anti-leukemia research, enabling insights into targeted therapeutic strategies. Its ability to specifically degrade CK1α makes it a valuable tool for investigating CK1α-related signaling pathways in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2564486-48-0 |
| Applications | CK1α Degrader |
| Formula | C21H16ClF3N4O4 |
| Molecular Weight | 480.82 |
| SMILES | O=C1CC[C@@H](N2CC3=C(C=CC(C(N[C@H](C4=NC=CC=C4Cl)C(F)(F)F)=O)=C3)C2=O)C(N1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.