Fig. 1 · Structure
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(R,S,S,R,S)-Boc-Dap-NE
MMAE Intermediate
(R,S,S,R,S)-Boc-Dap-NE serves as an inactive isomer of Boc-Dap-NE, primarily utilized as an experimental control in research settings. Boc-Dap-NE is an essential intermediate in the synthesis of Monomethyl auristatin E (MMAE), a potent inhibitor of tubulin polymerization. MMAE plays a critical role in the development of Antibody-Drug Conjugates (ADCs), functioning as an effective cytotoxic agent for targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2994330-72-0 |
| Applications | MMAE Intermediate |
| Formula | C23H36N2O5 |
| Molecular Weight | 420.54 |
| SMILES | O=C(N1[C@H](CCC1)[C@@H](OC)[C@H](C)C(N[C@@H](C)[C@H](O)C2=CC=CC=C2)=O)OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.