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(R,S)-Selitrectinib

Trk Inhibitor

(R,S)-Selitrectinib is a potent Trk inhibitor primarily targeting NTRK1, NTRK2, and NTRK3 genes. This compound demonstrates efficacy against cancers containing point mutations that confer resistance to conventional Trk inhibitors. (R,S)-Selitrectinib is essential for research applications focused on elucidating mechanisms of resistance in Trk-related tumors and developing therapeutic strategies for treatment-resistant cancer types.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2097002-59-8
Applications	Trk Inhibitor
Formula	C₂₀H₂₁FN₆O
Molecular Weight	380.42
Synonyms	(R,S)-LOXO-195
SMILES	FC(C=C1[C@]2([H])N(CCC2)C3=NC4=C5C=NN4C=C3)=CN=C1CC[C@H](C)NC5=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.