Fig. 1 · Structure
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(R)-SL18
ANXA3 Degrader
(R)-SL18 is an ANXA3 degrader that facilitates the degradation of ANXA3 protein via the ubiquitination pathway. It exhibits significant anti-cancer activity by inhibiting the proliferation, migration, invasion, and colony formation of breast cancer cells while inducing apoptosis. This compound is valuable for research focused on triple-negative breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3023189-40-1 |
| Applications | ANXA3 Degrader |
| Formula | C26H21ClN6O5S2 |
| Molecular Weight | 597.07 |
| SMILES | CN1C2=CC=CC=C2C(C3=CC=CC=C3)=N[C@@H](NC(SCC(NC(NC4=CC(Cl)=CC=C4[N+]([O-])=O)=O)=O)=S)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.