Fig. 1 · Structure

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(R)-SM875

PrP Degrader

(R)-SM875 is a prion protein (PrP) degrader that specifically targets its intermediate folding form. This compound effectively decreases PrP levels, demonstrating an IC50 of 3 μM. (R)-SM875 is suitable for research focused on prion diseases and related neurodegenerative disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Degrader
CAS Number 2715974-36-8
Applications PrP Degrader
Formula C19H16BrN3O3
Molecular Weight 414.25
SMILES
O=C1NC2=C(C=NN2C3=CC=C(C=C3)Br)[C@@H](C4=CC(OC)=C(C=C4)O)C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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