Fig. 1 · Structure
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(R)-Thionisoxetine hydrochloride
Norepinephrine Uptake Inhibitor
(R)-Thionisoxetine hydrochloride is a potent and selective norepinephrine uptake inhibitor, effectively blocking the reuptake of norepinephrine in both central and peripheral systems. It demonstrates significant efficacy in preventing hypothalamic norepinephrine depletion induced by 6-hydroxydopamine, with an ED50 value of 0.21 mg/kg. This compound is valuable for researching conditions such as depression and urinary incontinence, facilitating a deeper understanding of norepinephrine's role in these disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 222961-65-1 |
| Applications | Norepinephrine Uptake Inhibitor |
| Formula | C17H22ClNOS |
| Molecular Weight | 323.88 |
| Synonyms | LY-368975 hydrochloride |
| SMILES | CSC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.