Fig. 1 · Structure

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(R)-Ziftomenib

R-enantiomer of Ziftomenib

(R)-Ziftomenib is the R-enantiomer of Ziftomenib, an orally active inhibitor of the menin-MLL interaction. This compound exhibits significant antitumor activity and is primarily utilized in research focused on therapeutic strategies targeting MLL-rearranged leukemias. Its selective inhibition of menin provides a valuable tool for investigating the role of this pathway in cancer biology.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2134675-92-4
Applications R-enantiomer of Ziftomenib
Formula C33H42F3N9O2S2
Molecular Weight 717.87
Synonyms (R)-KO-539
SMILES
N#CC(N1C[C@H](N2CCN(S(=O)(C)=O)CC2)C)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC(NC)=N5)CC4)=C3C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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