Fig. 1 · Structure
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R121919 hydrochloride
CRF1R Antagonist
R121919 hydrochloride is a potent and selective antagonist of the corticotropin-releasing factor 1 receptor (CRF1R), exhibiting a binding affinity (Ki) in the range of 2 to 5 nM. This compound demonstrates notable antidepressant and anxiolytic effects, making it a valuable tool for research in stress, anxiety, and depression models. R121919 hydrochloride has been shown to effectively alleviate defensive withdrawal behaviors in rodent studies, supporting its potential use in neuropharmacological investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 195055-66-4 |
| Applications | CRF1R Antagonist |
| Formula | C22H33ClN6 |
| Molecular Weight | 416.99 |
| Synonyms | NBI30775 hydrochloride |
| SMILES | CCCN(CCC)C1=CC(C)=NC2=C(C3=C(C)C=C(N(C)C)N=C3)C(C)=NN12.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.