Fig. 1 · Structure
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R214127
mGlu1 Receptor Antagonist
R214127 is a selective antagonist of the mGlu1 receptor, exhibiting IC50 values of 6 nM for rat mGlu1a and 14 nM for human mGlu1a. This compound engages a site within the glutamate binding pocket, competing for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists. R214127 is utilized in research applications focusing on neuromodulation and the elucidation of mGlu1 receptor functions in various physiological and pathological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 409345-76-2 |
| Applications | mGlu1 Receptor Antagonist |
| Formula | C20H17NO2 |
| Molecular Weight | 303.35 |
| SMILES | O=C(CC1=CC=CC=C1)C2=CC3=CC4=C(OCCC4)N=C3C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.