Fig. 1 · Structure
Documents & Downloads
RA375
RPN13 Inhibitor
RA375 is an inhibitor of RPN13, a regulatory subunit of the 26S proteasome. This compound activates unfolded protein response (UPR) signaling, resulting in increased reactive oxygen species (ROS) production and induction of apoptosis. RA375 demonstrates superior potency, exhibiting ten-fold greater efficacy against cancer cell lines compared to RA190, likely due to its unique nitro ring substituents and the presence of a chloroacetamide warhead. This compound is valuable for research in cancer biology and therapeutic strategies targeting proteasomal pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2649154-57-2 |
| Applications | RPN13 Inhibitor |
| Formula | C30H25ClN4O7 |
| Molecular Weight | 589.00 |
| SMILES | O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=C\C3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.