Fig. 1 · Structure
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(rac)-AG-205
Pgrmc1 Inhibitor
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1), exerting significant effects on gene expression related to sterol synthesis, particularly influencing the INSIG1 protein that complexes with PGRMC1. This compound effectively mitigates neuronal resistance to hypoxic ischemia by inhibiting NF-kB signaling and disrupting the BDNF/PI3K/AKT pathway, making it a valuable tool for research in neuroprotection and cellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 442656-02-2 |
| Applications | Pgrmc1 Inhibitor |
| Formula | C22H23ClN6OS |
| Molecular Weight | 454.98 |
| SMILES | CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.