Fig. 1 · Structure
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(Rac)-BIO8898
CD40-CD154 PPI Inhibitor
(Rac)-BIO8898 is an inhibitor of the CD40-CD154 co-stimulatory interaction, functioning primarily by blocking the binding of CD154 to CD40-Ig, with an IC50 value of 25 μM. This compound is valuable in research applications focused on modulating immune responses, particularly in the context of autoimmune diseases and transplantation. Its role in inhibiting CD40-CD154 signaling can aid in the investigation of therapeutic strategies targeting immune regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 402564-79-8 |
| Applications | CD40-CD154 PPI Inhibitor |
| Formula | C53H64N8O6 |
| Molecular Weight | 909.13 |
| SMILES | O=C(O)C(NC(C1=NC(C(N2C(CN3CCCC3)CCC2)=O)=CC(C4=CC(C(NCC5=CC(C6=CC=CC=C6)=CC=C5)=O)=NC(C(N7C(CN8CCCC8)CCC7)=O)=C4)=C1)=O)C9CCCCC9 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.