(Rac)-BMS-816336 is a potent inhibitor of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, exhibiting IC50 values of 10 nM in human cells and 68 nM in murine cells. Its mechanism of action involves the selective inhibition of 11β-HSD1, leading to modulation of glucocorticoid metabolism. This compound is useful in research applications focused on metabolic disorders, obesity, and conditions associated with dysregulated glucocorticoid action, due to its favorable metabolic stability.
(Rac)-BMS-816336 is a potent inhibitor of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, exhibiting IC50 values of 10 nM in human cells and 68 nM in murine cells. Its mechanism of action involves the selective inhibition of 11β-HSD1, leading to modulation of glucocorticoid metabolism. This compound is useful in research applications focused on metabolic disorders, obesity, and conditions associated with dysregulated glucocorticoid action, due to its favorable metabolic stability.
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