Fig. 1 · Structure
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(Rac)-CCT 250863
NEK 2 Inhibitor
(Rac)-CCT 250863 is a selective and reversible inhibitor of NEK 2, with an IC50 of 0.073 µM. This compound effectively induces cell cycle arrest and demonstrates antiproliferative activity in both Pomalidomide-sensitive and resistant cell lines. Additionally, (Rac)-CCT 250863 promotes apoptosis when used in combination with Pomalidomide, making it a valuable tool for research in cancer therapeutics and cell cycle regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1364269-06-6 |
| Applications | NEK 2 Inhibitor |
| Formula | C24H25F3N4O2S |
| Molecular Weight | 490.54 |
| SMILES | O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.