(Rac)-Lanicemine is a potent NMDA receptor antagonist that functions as a low-trapping blocker of NMDA channels, exhibiting a Ki value between 0.56-2.1 μM. This compound demonstrates antidepressant properties, supported by IC50 values of 4-7 μM in CHO cells and 6.4 μM in Xenopus oocyte cells. Its unique pharmacological profile makes (Rac)-Lanicemine valuable for research investigating the mechanisms of depression and the role of NMDA receptors in neuropsychiatric disorders.
(Rac)-Lanicemine is a potent NMDA receptor antagonist that functions as a low-trapping blocker of NMDA channels, exhibiting a Ki value between 0.56-2.1 μM. This compound demonstrates antidepressant properties, supported by IC50 values of 4-7 μM in CHO cells and 6.4 μM in Xenopus oocyte cells. Its unique pharmacological profile makes (Rac)-Lanicemine valuable for research investigating the mechanisms of depression and the role of NMDA receptors in neuropsychiatric disorders.
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