Fig. 1 · Structure
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(Rac)-P1D-34
PIN1 PROTAC Degrader
(Rac)-P1D-34 is a PROTAC-based degrader targeting the PIN1 protein, utilizing cereblon as the E3 ligase for targeted degradation. This compound exhibits anti-cancer activity with reported IC50 values of 2248 nM in MV-4-11 cells and 3984 nM in MOLM-13 cells, demonstrating its potential in hematological malignancies. Its application as a research tool in the study of cancer biology and therapeutic development for cancers associated with PIN1 overexpression is notable.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2957895-04-2 |
| Applications | PIN1 PROTAC Degrader |
| Formula | C40H59ClN6O9S |
| Molecular Weight | 835.45 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(NCCCCCCCCCCCCNC(CCC(NCC(C)(CN(C4CCS(=O)(C4)=O)C(CCl)=O)C)=O)=O)C=C3C2=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.