Fig. 1 · Structure
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(Rac)-Plevitrexed
Plevitrexed Racemate
(Rac)-Plevitrexed is a potent inhibitor of thymidylate synthase (TS) and serves as a racemic mixture of Plevitrexed. This compound exhibits significant biological activity in cancer research due to its ability to impede DNA synthesis by disrupting folate metabolism. Additionally, (Rac)-Plevitrexed features an alkyne group, enabling its application in click chemistry for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for bioconjugation and labeling studies in biochemical research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 153538-08-0 |
| Applications | Plevitrexed Racemate |
| Formula | C26H25FN8O4 |
| Molecular Weight | 532.53 |
| Synonyms | (Rac)-ZD 9331; (Rac)-BGC9331 |
| SMILES | O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(NC(C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.