Fig. 1 · Structure

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(Rac)-Tipifarnib

Farnesyl Transferase Inhibitor

(Rac)-Tipifarnib is a potent farnesyl protein transferase inhibitor that disrupts the post-translational modification of Ras proteins. By inhibiting farnesylation, it effectively interferes with the activation and function of Ras, leading to significant antitumor effects. This compound is utilized in research focused on cancer therapeutics and the molecular mechanisms underlying Ras-mediated signaling pathways.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 192185-68-5
Applications Farnesyl Transferase Inhibitor
Formula C27H22Cl2N4O
Molecular Weight 489.40
Synonyms (Rac)-IND 58359; (Rac)-R115777
SMILES
O=C1N(C2=C(C(C3=CC=CC(Cl)=C3)=C1)C=C(C=C2)C(N)(C4=CN=CN4C)C5=CC=C(C=C5)Cl)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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