Fig. 1 · Structure
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Rafutrombopag (tautomerism)
TPOR/MPL Agonist
Rafutrombopag is a nonpeptide agonist of the thrombopoietin receptor (TPOR/MPL) that exhibits oral bioactivity. This compound promotes hematopoiesis and alleviates iron overload by chelating iron, stimulating the proliferation and differentiation of TPOR-expressing cells, such as human hematopoietic stem cells. Rafutrombopag activates critical signaling pathways, including STAT, PI3K, and ERK, leading to the upregulation of cell cycle-related proteins and modulation of apoptosis. It also offers protective effects on cardiomyocytes under oxidative stress, making it a valuable tool for researching conditions such as immune thrombocytopenia and cardiovascular diseases linked to oxidative stress.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2114365-78-3 |
| Applications | TPOR/MPL Agonist |
| Formula | C25H22N4O5 |
| Molecular Weight | 458.47 |
| Synonyms | Hetrombopag (tautomerism); SHR-8735 (tautomerism) |
| SMILES | O=C(C1=CC=C(C2=C(O)C(/N=N/C3C(N(C4=CC=C5C(CCCC5)=C4)N=C3C)=O)=CC=C2)O1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.