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RAGE406R

RAGE-DIAPH1 Interaction Antagonist

RAGE406R is a potent antagonist of the RAGE-DIAPH1 interaction, functioning by binding to ctRAGE and disrupting the formation of the RAGE-DIAPH1 complex. This compound has demonstrated the ability to significantly reduce the expression of pro-inflammatory cytokines, including CCL2, TNF, and IL-6 in THP1 cells. Additionally, RAGE406R has shown efficacy in suppressing delayed-type hypersensitivity in models of Type 2 Diabetes, making it a valuable tool for studying diabetes-related inflammatory processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3034560-21-6
Applications	RAGE-DIAPH1 Interaction Antagonist
Formula	C₂₅H₂₄N₄O₂
Molecular Weight	412.48
SMILES	N#CC1=CC=C2C(CN3CCOCC3)=CC(C4=CC=C(C=C4)[C@H]5CCC(N5)=O)=NC2=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.