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Ragifilimab

Ragifilimab (INCAGN-1876) is an agonistic monoclonal antibody designed to specifically target the glucocorticoid-induced TNFR-related protein (GITR). This antibody has been developed for use in research involving advanced or metastatic solid tumors, exploring its potential to modulate immune responses and enhance anti-tumor activity. Ragifilimab provides a valuable tool for investigating the therapeutic implications of GITR activation in oncological studies.

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Biological Activity

Target & Activity

GITR

Product Details

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 2207590-51-8
Molecular Weight 146460
Synonyms INCAGN-1876

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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