Fig. 1 · Structure
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RB-005
SK1 Inhibitor
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1), exhibiting an IC50 value of 3.6 µM, while demonstrating weaker inhibition of the isoenzyme SK2. This selective targeting of SK1 allows for the investigation of its distinct biological functions and roles, making RB-005 valuable in research on inflammatory diseases and cancer. Its specificity facilitates the exploration of SK1-mediated signaling pathways in various cellular contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1425049-20-2 |
| Applications | SK1 Inhibitor |
| Formula | C21H35NO |
| Molecular Weight | 317.51 |
| SMILES | CCCCCCCCC1=CC=C(CCN2CCC(O)CC2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.