Fig. 1 · Structure
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RB-3
PRC1 Inhibitor
RB-3 is a potent inhibitor of the Polycomb Repressive Complex 1 (PRC1), specifically targeting the RING1B-BMI1 complex with a binding affinity (Kd) of 2.8 μM. This compound is instrumental in studying epigenetic regulation and gene expression, as well as investigating the role of PRC1 in oncogenic processes. RB-3 provides valuable insights into PRC1-mediated transcriptional repression, making it a useful tool for cancer research and epigenetic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2396639-11-3 |
| Applications | PRC1 Inhibitor |
| Formula | C24H20ClN3O2 |
| Molecular Weight | 417.89 |
| SMILES | O=C(C1=C(C2=C3C=CNC3=CC=C2Cl)C(C(C)C)=C(C4=C5C=CNC5=CC=C4)N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.