Fig. 1 · Structure
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RDN2150
ZAP-70 Inhibitor
RDN2150 is a selective ZAP-70 inhibitor with an IC50 of 14.6 nM. This compound covalently interacts with the C346 residue of ZAP-70, effectively diminishing the expression of activation markers such as CD25 and CD69, thereby inhibiting CD4+ T cell activation. RDN2150 is suitable for research applications related to T cell regulation and the investigation of psoriasis mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2839429-51-3 |
| Applications | ZAP-70 Inhibitor |
| Formula | C28H29ClN8O4 |
| Molecular Weight | 577.03 |
| SMILES | O=C(C1=C(N=C(N2C1=NC=C2)NCC3=CC(NC(C=C)=O)=C(C=C3)Cl)NC4=CC(OC)=C(C=C4)N5CCOCC5)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.