Fig. 1 · Structure
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Regorafenib mesylate
Multi-kinase Inhibitor
Regorafenib mesylate is a potent multi-kinase inhibitor that targets multiple receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET, and Raf-1, with IC50 values ranging from 1.5 to 46 nM. This compound exhibits significant antitumor and antiangiogenic properties, making it an essential tool for cancer research. Regorafenib mesylate is widely used to investigate pathways involved in tumor growth and angiogenesis, offering valuable insights into potential therapeutic strategies for cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 835621-08-4 |
| Applications | Multi-kinase Inhibitor |
| Formula | C22H19ClF4N4O6S |
| Molecular Weight | 578.92 |
| Synonyms | BAY 73-4506 mesylate |
| SMILES | O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.CS(O)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.