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rel-A-395 hydrochloride

Relative Configuration of A-395

rel-A-395 hydrochloride is an antagonist of polycomb repressive complex 2 (PRC2), specifically designed to disrupt protein-protein interactions within the trimeric PRC2 complex, comprising EZH2, EED, and SUZ12. With an IC50 value of 18 nM, this compound effectively inhibits PRC2 activity, making it a valuable tool for research on epigenetic regulation and gene expression modulation. Its application is crucial in studies aimed at understanding the role of PRC2 in oncogenesis and developmental biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2747996-65-0
Applications	Relative Configuration of A-395
Formula	C₂₆H₃₆ClFN₄O₂S
Molecular Weight	523.11
SMILES	O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.