Fig. 1 · Structure
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Remeglurant
mGlu5 Antagonist
Remeglurant is a selective, orally active allosteric antagonist of the metabotropic glutamate receptor 5 (mGlu5) with an IC50 of 13 nM. This compound demonstrates significant potential in advancing research related to dyskinesia in Parkinson's disease (PD). It is valuable for studies investigating the modulation of glutamatergic signaling and its impact on movement disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1309783-00-3 |
| Applications | mGlu5 Antagonist |
| Formula | C17H15BrN4O |
| Molecular Weight | 371.23 |
| Synonyms | MRZ-8456 |
| SMILES | O=C(N1[C@@H](C2=C(CC1)C=CC=C2)C)C3=NN4C=C(C=NC4=C3)Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.