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Reslizumab

Reslizumab (Sch 55700) is a humanized monoclonal antibody designed to specifically target and neutralize interleukin-5 (IL-5), a key cytokine involved in the pathogenesis of eosinophilic asthma. This antibody exhibits a high binding affinity for human IL-5, demonstrating dissociation constants (K_D) of 109 pM and 4.3 pM in Biacore surface plasmon resonance and Kinetic Exclusion Assay analyses, respectively. By inhibiting the activity of IL-5, Reslizumab effectively reduces the growth and survival of eosinophils, thereby mitigating the inflammatory processes associated with eosinophilic asthma. This makes Reslizumab a critical tool in the therapeutic management of this condition.

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Biological Activity

Target & Activity

IL-5

91.1 pM (IC50)

Product Details

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 241473-69-8
Synonyms Sch 55700

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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