RET-IN-1

Catalog No.: A19015

RET inhibitor

RET-IN-1

RET-IN-1 Chemical Structure

CAS NO. 2222755-14-6

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.32 mL 180.63 mL
0.5 mM 3.61 mL 18.06 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19015
Actions Inhibitor
M. Wt 553.61
Formula C29H31N9O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2222755-14-6
SMILES N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[[email protected]]7CNCCO7)=CN2N=C1

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