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RET-IN-11

RET Inhibitor

RET-IN-11 is a potent and selective inhibitor of the RET receptor tyrosine kinase, exhibiting IC50 values of 6.20 nM for RET and 18.68 nM for the RETV804M mutation. This compound demonstrates significant anti-proliferative and anti-migratory effects in CCDC6-RET-driven LC-2/ad cells. Additionally, RET-IN-11 promotes apoptosis, making it a valuable tool for research in cancer biology and targeted therapies for RET-related malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2764891-88-3
Applications	RET Inhibitor
Formula	C₂₇H₃₀FN₉O
Molecular Weight	515.59
SMILES	O=C(NC1=CC=CC(F)=C1)CC2=CC=C(NC3=NC(N4CCN(C)CC4)=CC(NC5=CC(C)=NN5)=N3)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.