Fig. 1 · Structure
Documents & Downloads
RET-IN-13
RET Inhibitor
RET-IN-13 is a potent inhibitor of the RET proto-oncogene, exhibiting IC50 values of 0.5 nM for wild-type RET and 0.9 nM for the RET V804M mutant. This quinoline compound demonstrates significant efficacy in targeting RET-mediated signaling pathways, making it a valuable tool for investigating tumors and intestinal diseases associated with aberrant RET activation. Its application in research may provide insights into the therapeutic potential of RET inhibition in various oncological and gastrointestinal conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2684258-54-4 |
| Applications | RET Inhibitor |
| Formula | C32H33F4N5O3 |
| Molecular Weight | 611.63 |
| SMILES | O=C(CC1=CC=C(C2=CN=C3C=C(C(OC)=CC3=C2)OC)N=C1)NC4=C(F)C=C(CN5CCN(CC5)CC)C(C(F)(F)F)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.