Fig. 1 · Structure
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RET-IN-15
RET Inhibitor
RET-IN-15 is a potent inhibitor of the rearranged during transfection (RET) kinase. It demonstrably impedes RET signaling pathways, contributing to the inhibition of tumor cell proliferation in various cancers. This compound is suitable for research applications exploring the role of RET in oncogenesis and therapeutic interventions targeting RET-driven malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2643375-86-2 |
| Applications | RET Inhibitor |
| Formula | C27H28N8O2 |
| Molecular Weight | 496.56 |
| SMILES | N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(NCCO)=CN2N=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.