Fig. 1 · Structure
Documents & Downloads
RET-IN-19
RET Inhibitor
RET-IN-19 is a potent inhibitor of the RET receptor tyrosine kinase, exhibiting IC50 values of 6.8 nM for RET wild-type and 13.51 nM for the RET V804M mutant. This compound demonstrates significant anticancer activity, making it a valuable tool in the study of non-small cell lung cancer (NSCLC). RET-IN-19 is suitable for research focused on targeted therapy and the mechanisms of RET-mediated oncogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2484919-71-1 |
| Applications | RET Inhibitor |
| Formula | C28H28N6O4S |
| Molecular Weight | 544.62 |
| SMILES | O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(NC3=C4C(NC(C5=CC=C(S(=O)(C)=O)C=C5)=C4)=NC=N3)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.