Fig. 1 · Structure
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RET-IN-21
RETV804M Inhibitor
RET-IN-21 is a selective inhibitor of the RETV804M mutant variant with an IC50 of 0.02 μM. This compound exhibits specificity, showing no significant inhibition of wild type RET or KDR isoforms. RET-IN-21 demonstrates notable antitumor activity, making it a valuable tool for research into targeted therapies for RETV804M-driven malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2414373-42-3 |
| Applications | RETV804M Inhibitor |
| Formula | C19H16N6O |
| Molecular Weight | 344.37 |
| SMILES | O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=NC=C4)C=CN3N=C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.