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RET-IN-28

RET Inhibitor

RET-IN-28 is a selective inhibitor of the RET (rearranged during transfection) receptor tyrosine kinase. It effectively targets and inhibits the activity of the mutant RET enzyme, specifically RET-V804M, making it valuable for investigations into oncogenic signaling pathways. This compound is primarily utilized in cancer research to study the role of RET mutations in tumorigenesis and therapeutic resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2479961-45-8
Applications	RET Inhibitor
Formula	C₂₆H₂₉N₉
Molecular Weight	467.57
SMILES	CC(C=C1)=NC=C1CN(C(C2)C3)C2CN3C4=NC=C(C5=NC(NC6=NNC(C)=C6)=CC(C)=N5)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.