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RET-IN-31

RET Inhibitor

RET-IN-31 is a selective inhibitor of RET, demonstrating high potency with IC50 values of 1.4 nM for RETWT, 1.9 nM for RETV804L, and 3.8 nM for RETV804M. This compound exhibits anti-cancer activity against malignancies driven by activated RET mutations and gene fusions. Additionally, RET-IN-31 has been characterized for its inhibitory effects on hERG and various Cytochrome P450 enzymes, making it a valuable tool for exploring RET-related signaling pathways in cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2491726-04-4
Applications	RET Inhibitor
Formula	C₂₄H₂₅FN₁₀O
Molecular Weight	488.52
SMILES	CC1=CC(NC2=CC(C)=NC(N3CC4N(C(C5=CN=C(N6N=CC(F)=C6)C=C5)=O)C(CC4)C3)=N2)=NN1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.