Fig. 1 · Structure
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RET-IN-5
RET Inhibitor
RET-IN-5 is a potent RET (rearranged during transfection) inhibitor, exhibiting an IC50 value of 0.4 nM against RET and 135.1 nM against VEGFR2. This compound is designed for research applications focusing on RET-mediated signaling pathways and its role in various cancers. Its selectivity and efficacy make it a valuable tool for understanding RET inhibition and its potential therapeutic implications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2725770-20-5 |
| Applications | RET Inhibitor |
| Formula | C29H26FN9O |
| Molecular Weight | 535.57 |
| SMILES | N#CC1=C2C(C3=CN=C(N(C)[C@H](C4=CN=C(N5C=C(C=N5)F)C=C4)C)C=C3)=CC(OCC(C)(C)C#N)=CN2N=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.