Fig. 1 · Structure
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RET-IN-6
RET Inhibitor
RET-IN-6 is a potent inhibitor of RET (rearranged during transfection) with an IC50 value of 4.57 nM. This compound effectively blocks RET signaling pathways, making it a valuable tool for research on RET-driven cancers and other related diseases. Its high specificity and efficacy facilitate investigations into therapeutic options for malignancies characterized by RET alterations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2715208-83-4 |
| Applications | RET Inhibitor |
| Formula | C30H29N7 |
| Molecular Weight | 487.60 |
| SMILES | CN1C=C(C=N1)C2=CC3=C(C=CC=N3)C(C4=CN=C(N(CC5CC6)CC6N5CC7=CC=CC=C7)C=C4)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.