Fig. 1 · Structure
Documents & Downloads
RET-IN-9
RET Inhibitor
RET-IN-9 is a potent inhibitor of RET (rearranged during transfection) kinase, a receptor tyrosine kinase crucial for the development of the kidney and enteric nervous system. This compound demonstrates significant biological activity by targeting RET, making it a valuable tool in the study of RET-related disorders, including non-small cell lung cancer and medullary thyroid cancer. Its application in research can deepen the understanding of RET's role in various physiological systems and disease states.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2649418-11-9 |
| Applications | RET Inhibitor |
| Formula | C26H27N9O |
| Molecular Weight | 481.55 |
| SMILES | N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(NCC)=CN2N=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.