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RET ligand-2

RET Inhibitor

RET ligand-2 is a selective inhibitor of the RET protein, primarily involved in oncogenic signaling pathways. It serves as a critical ligand for the development of PROTAC molecules aimed at degrading the RET protein, demonstrating potential antitumor activity. This compound can also be utilized in the synthesis of RD-23, facilitating research into targeted cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3053537-08-6
Applications	RET Inhibitor
Formula	C₃₄H₃₈N₁₀O
Molecular Weight	602.73
SMILES	COC1=NC=C(C=C1)CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(N6CC=C(CC6)N7CCNCC7)=CN8N=CC(C#N)=C58

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.