Fig. 1 · Structure
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RET V804M-IN-1
RET Inhibitor
RET V804M-IN-1 is a selective inhibitor targeting the RETV804M kinase, with an IC50 of 20 nM. This compound demonstrates potent inhibition of wild-type RET, making it a valuable tool for studying RET-mediated signaling pathways. Its specificity for RETV804M positions it as an important reagent for research applications in cancer biology and targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2414909-94-5 |
| Applications | RET Inhibitor |
| Formula | C19H16N6O |
| Molecular Weight | 344.37 |
| SMILES | O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=CN=C4)C=CN3N=C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.