Fig. 1 · Structure
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RETRA hydrobromide
p73 Activator
RETRA hydrobromide is a potent activator of p73, particularly effective in p53 mutant cancer cells. It enhances the expression of p73, initiating transcriptional activation of key targets associated with p53 and p73 pathways. This results in the inhibition of tumor growth, a decrease in colony formation, and the activation of effector caspases, making RETRA a valuable tool for cancer research focused on p53 mutations and p73 modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1035875-01-4 |
| Applications | p73 Activator |
| Formula | C11H12BrNO3S2 |
| Molecular Weight | 350.25 |
| SMILES | O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O.Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.